Bio
My Story
I am Biochemist by training. The scientific journey of mine has started from University of Hyderabad, where I have done my Master of Science in Biochemistry. The excellent scientific temperament there has nurtured and made me passionate to follow my dream of research in biomedical sciences. I have done Ph.D. from University of Hyderabad in Biochemistry. Then, I joined University of Pennsylvania, Department of Microbiology, Philadelphia, USA for postdoctoral training. Currently, I'm working as Assistant Professor, Department of Biochemistry at Jamia Hamdard University, an Institute of Eminence declared by Govt. of India.
My Research
Infection Biology: Studying Molecular Mechanisms & Disease Modeling
I am interested in studying the Bacterial Stress Biology, Molecular Mechanisms of Infectious Diseases, and Modeling of Infectious Diseases. My long-term goal is to identify and characterize the molecular mechanisms and underlying principles specific to these areas of research. Read more about these projects below.
Bacterial Stress Biology
Stress Response Mechanisms of pathogenic bacteria aid them to sustain the inhospitable host environment and also to tolerate the stress born due to antibiotic and environmental stimuli. Bacterial communities make biofilms, deploy small accessory chaperones are few of the ways to tolerate stresses. Some foldases like PPIasese show protein moonlighting and act as an accessory chaperone and are part of bacterial stress response mechanisms
Infection Biology and Disease Modeling
I have exposure to work on several infection agents like Mycobacterium tuberculosis causing TB, Helicobacter pylori causing gastric cancer and Epstein-Barr Viruses responsible for tumorigenesis in humans. We have shown H. pylori and EBV co-operate and large scale epigenetic alteration enhances gastric cancer.
My lab is also interested to expand work in modeling infection outbreaks of both bacterial and viral origin. Also to apply modern machine learning methods to public health, genomics and transcriptomics data sets of the public domain to reveal the hidden patterns and develop predictive hazard modeling. It will be fascinating to apply them on emerging infectious diseases.
Publications
Periwal N, Sharma P, Arora P, Pandey S, Kaur B, Sood V (2022); A Novel Binary k-mer Approach for Classification of Coding and Non-coding RNAs Across Diverse Species, Biochimie, DOI: 10.1016/j.biochi.2022.04.012, IF = 4.08, (ISSN 0300-9084)
Ahmad F, Rani A, Alam A, Zarin S, Pandey S, Singh H, Hasnain SE and Ehtesham NZ (2022); Macrophage: A cell with many faces and functions in tuberculosis, Frontiers in Immunology; DOI: 10.3389/fimmu.2022.747799, IF=7.561 (ISSN 1664-3224)
Pandey S, Kant S, Khawary M, Tripathi D (2022); Macrophages in Microbial Pathogenesis: Commonalities of Defense Evasion Mechanisms, Infection and Immunity, DOI:10.1128/IAI.00291-21 (ISSN 0019-9567)
Pandey S, Raunak, Tripathi T, Khawary M, Tripathi D, Kant S ( 2022); Chapter 10 - Molecular Mechanisms of Stress Adaptation by Bacterial Communities, Editors: Raghvendra Pratap Singh, Geetanjali Manchanda, Kausik Bhattacharjee, Hovik Panosyan; Microbial Syntrophy-Mediated Eco-Enterprising (1st edition), Academic Press, ISBN: 0323913962, DOI: 10.1016/B978-0-323-99900-7.00013-4
Rani M, Paul B, Bhattacharjee A, Das K, Singh P, Basu S, Pandey S, Tripathi D, Kumar A (2022); Chapter 13 - Detection and Removal of Pathogenic Bacteria from Wastewater Using Various Nanoparticles, Editors: Maulin Shah, Susana Rodriguez-Couto, Jayanta Biswas; Development in Wastewater Treatment Research and Processes, Elsevier, Pages 311-322, ISBN 9780323855839, DOI:10.1016/B978-0-323-85583-9.00025-9.
Rani M, Bhattacharjee A, Singh P, Basu S, Das K, Goswami K, Pandey S, Tripathi D, Kumar A (2022); Chapter 22 - Antimicrobial Activities of Different Nanoparticles Concerning to Wastewater Treatment, Editors: Maulin Shah, Susana Rodriguez-Couto, Jayanta Biswas, Development in Wastewater Treatment Research and Processes, Elsevier, Pages 501-514, ISBN 9780323855839, DOI:10.1016/B978-0-323-85583-9.00029-6.
Minocha S, Khadgawat P, Bhattacharjee A, Kumar A, Tripathi T, Pandey S, Tripathi D (2021); Role of Microbial Nanotechnology in Diagnostics. In: Ansari M.A., Rehman S. (eds) Microbial Nanotechnology: Green Synthesis and Applications. Springer, Singapore, ISBN: 978-981-16-1922-9, DOI:10.1007/978-981-16-1923-6_12
Bharadwaj P, Tripathi D, Pandey S, Tapadar S, Das D, Palwan E, Rani M and Kumar A (2021); Molecular Biology techniques for the detection of contaminants in wastewater; Book: Wastewater Treatment: Cutting Edge Molecular Tools, Techniques and Applied Aspects, (edited by Maulin P. Shah, Angana Sarkar, Sukhendu Mandal) Elsevier, ISBN: 9780128218815, DOI: 10.1016/B978-0-12-821881-5.00010-6
Pandey S, Yadav B, Pandey A, Tripathi T, Khawary M, Kant S, Tripathi D (2020); Lessons from SARS-CoV-2 Pandemic: Evolution, Disease Dynamics and Future, Biology; 9:141; doi:10.3390/biology9060141, IF=5.079; (ISSN: 2079-7737)
Tripathi D, Kant S, Pandey S#, Nasreen Z Ehtesham#, (2020), Resistin in Metabolism, Inflammation and Disease, The FEBS Journal, DOI: 10.1111/febs.15322; IF = 5.542, (ISSN: 1742-464X), # Corresponding Authors
Pandey S., Shukla N., Singh S.S., Tripathi D., Tripathi T., Kant S. (2020) Bacterial Metabolic Fitness During Pathogenesis. In: Singh R., Manchanda G., Maurya I., Wei Y. (eds) Microbial Versatility in Varied Environments. Springer, Singapore (DOI: 10.1007/978-981-15-3028-9_12) (ISBN: 978-981-15-3028-9)
Tapadar S, Goswami K, Tripathi D, Pandey S, Palwan E, Rani M, Kumar A (2020); Role of Extremophiles and Extremophilic Proteins in Industrial Waste Treatment; Book: Removal of Emerging Contaminants Through Microbial Processes (ISBN 9789811559006) (Editors: Moulin P Shah), Springer. ISBN 9789811559006, DOI:10.1007/978-981-15-5901-3_11
Hasnain S E, Ehtesham N Z, Tripathi D, Grover S, Kumar A, Alam A, Pandey S (2020) A medicament for the treatment of diseases by biofilm forming microorganisms, PATENT Publication (USA, Application Number 16607061)
Tripathi D., Pandey S., Kant S. (2020) Biosensors: Current Trends, Lalpawimawha, Lalmuanpuia Vanchhawng, B. Lalruatfela (eds), Book: Proceedings of National Workshop on Sensor Networks, Internet of Things and Internet of Everything, Notionpress, Chennai, India, ISBN 978-1-64760-657-2
Kumar A#, Alam A#, Grover S#, Pandey S#, Tripathi D, Kumari M, Rani M, Singh A, Akhter Y, Ehtesham NZ, Hasnain SE (2019), Peptidyl-prolyl isomerase-B is involved in Mycobacterium tuberculosis biofilm formation and a generic target for drug repurposing-based intervention. npj Biofilms and Microbiomes, 5:3, IF = 7.290 #equal first author; DOI:10.1038/s41522-018-0075-0; (ISSN No 2055-5008)
Gupta MN, Pandey S, Ehtesham NZ, Hasnain SE (2019), Medical Implications of Protein Moonlighting, Indian Journal of Medical Research; 149:322-325, DOI: 10.4103/ijmr.IJMR_2192_18, IF = 2.375, (ISSN: 0971-5916)
Pandey S, Ahmed J, Ehtesham NZ, (2019), Chaperone-like proteins in Inflammation and Immunomodulation: Examples of Resistin and PPIases. In: Book Chapter: Chaperokine Activity of Heat Shock Proteins; (Editors: Asea, Alexzander A. A., Kaur, Punit), (DOI:10.1007/978-3-030-02254-9_9), (ISBN No 978-3-030-02253-2), Springer Nature.
Pandey S, Jha HC, Shukla SK, Shirley MK, Robertson ES, (2018) Epigenetic Regulation of Tumor Suppressors by Helicobacter pylori enhances EBV-induced proliferation of Gastric epithelial cells. mBio 9(2): e00649-18, DOI:10.1128/mBio.00649-18, IF = 7.867, (ISSN 2150-7511)
Kumar A, Alam A, Tripathi D, Rani M, Khatoon H, Pandey S, Ehtesham NZ, Hasnain SE (2018). Protein adaptations in extremophiles: An insight into extremophilic connection of mycobacterial proteome, Seminars in Cell and Developmental Biology; 84:147–157 DOI: 10.1016/j.semcdb.2018.01.003, IF=7.727, (ISSN 1084-9521)
Pandey S, Tripathi D, Khubaib M, Kumar A, Shaikh J, Ehtesham NZ, Hasnain SE, (2017), Mycobacterium tuberculosis peptidyl-prolyl isomerases show immunogenicity, alter cytokine profile and aid in intracellular survival; Front. Cell. Infect. Microbiol. 7:38. DOI:10.3389/fcimb.2017.00038; IF = 5.293, (ISSN 2235-2988)
Sharma A, Equbal MJ, Pandey S, Shaikh J, Ehtesham NZ, Hasnain SE, Chaudhuri TK, (2017), Immunodominant protein MIP_05962 from Mycobacterium indicus pranii displays chaperone activity; The FEBS Journal, 284(9):1338-1354, DOI: 10.1111/febs.14057; IF = 5.542, (ISSN 1742-464X)
Pandey S, Erle S Robertson (2017); Oncogenic Epstien-Barr Virus Recruits Nm23-H1 To Regulate Chromatin Modifiers, Laboratory Investigation, DOI: 10.1038.laninvest.2017.112, IF=5.662 (ISSN 0023-6837)
Pandey S, Sharma A, Tripathi D, Kumar A, Khubaib M, Bhuwan M, Chaudhuri TK, Hasnain SE, Ehtesham NZ, (2016), Mycobacterium tuberculosis peptidyl-prolyl isomerases also exhibits chaperone like activity in vitro and in vivo; PLoS One, 11(3):e0150288. DOI:10.1371/journal.pone.0150288.IF = 3.24, (ISSN 1932-6203)
Khubaib M#, Sheik JA#, Pandey S#, Shrikanth B, Bhuwan M, Khan N, Hasnain SE, Ehtesham NZ, (2016), Mycobacterium tuberculosis co-operonic PE32/PPE65 proteins alter host immune responses by hampering Th1 response, Frontiers in Microbiology, 7: 719 DOI: 10.3389/fmicb.2016.00719; IF=5.640, #Contributed as equal first author. (ISSN 1664-302X)
Bhuwan M, Arora N, Sharma A, Khubaib M, Pandey S, Chaudhuri TK, Ehtesham NZ, Hasnain SE, (2016), Interaction of Mycobacterium tuberculosis virulence factor RipA with MoxR1, a chaperone, is required for transport through TAT secretion system, mBio, DOI:10.1128/mBio.02259-15; IF=7.867, (ISSN 2150-7511)
Suragani M, Aadinarayana VD, Pinjari AB, Tanneeru K, Guruprasad L, Banerjee S, Pandey S, Chaudhuri TK, Ehtesham NZ, (2013), Human resistin, A proinflammatory cytokine, shows chaperone-like activity; Proc Natl Acad Sci USA; 110(51):20467-72. DOI:10.1073/pnas.1306145110; IF=11.205, (ISSN 1091-6490)
Patent
“A medicament for the treatment of diseases by biofilm forming microorganisms.” Pub No: WO/2018/193477, Application No: PCT/IN2018/050238, Publication date: 25.10.2018, International Filing Date: 20.04.2018.
Research Grant
UGC Startup grant (2019-2022)-10 Lakhs, “Investigating the role of Trigger factor in stress tolerance and virulence"
Gallery
Contact Me
Dr. Saurabh Pandey, Room No-4, Department of Biochemistry, Jamia Hamdard (Deemed to be University), New Delhi, 110062, India
+91-6376705310